Protein Language Models

Few-shot Protein Fitness Prediction via In-context Learning and Test-time Training

Accurately predicting protein fitness with minimal experimental data is a persistent challenge in protein engineering. We introduce PRIMO (PRotein In-context Mutation Oracle), a …

Multi-Scale Representation Learning for Protein Fitness Prediction featured image

Multi-Scale Representation Learning for Protein Fitness Prediction

Designing novel functional proteins crucially depends on accurately modeling their fitness landscape. Given the limited availability of functional annotations from wet-lab …