Protein Fitness Prediction

Few-shot Protein Fitness Prediction via In-context Learning and Test-time Training

Accurately predicting protein fitness with minimal experimental data is a persistent challenge in protein engineering. We introduce PRIMO (PRotein In-context Mutation Oracle), a …

Evolutionary Models

Augmenting Evolutionary Models with Structure-Based Retrieval

Multiple Sequence Alignments (MSAs) are crucial in protein sequence analysis for identifying homologous proteins sharing a common evolutionary origin. However, traditional MSA …

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Protein Fitness Prediction

Few-shot Protein Fitness Prediction via In-context Learning and Test-time Training

Augmenting Evolutionary Models with Structure-Based Retrieval